Proteases — invasion and more
نویسندگان
چکیده
منابع مشابه
Functional Analysis of Rhomboid Proteases during Toxoplasma Invasion
Host cell invasion by Toxoplasma gondii and other apicomplexan parasites requires transmembrane adhesins that mediate binding to receptors on the substrate and host cell to facilitate motility and invasion. Rhomboid proteases (ROMs) are thought to cleave adhesins within their transmembrane segments, thus allowing the parasite to disengage from receptors and completely enter the host cell. To ex...
متن کاملTube travel: the role of proteases in individual and collective cancer cell invasion.
Recent advances in high-resolution multimodal microscopy reveal how MT1-matrix metalloproteinase (MMP)/MMP-14 and other cell surface proteases degrade and remodel the extracellular matrix (ECM) to drive the dissemination of cancer cells into normal adjacent tissue. By cleaving collagen fibers and repatterning them into parallel bundles, individual cells reorient the ECM to permit movement in tu...
متن کاملDifferential Expressions of Adhesive Molecules and Proteases Define Mechanisms of Ovarian Tumor Cell Matrix Penetration/Invasion
Epithelial ovarian cancer is an aggressive and deadly disease and understanding its invasion mechanisms is critical for its treatment. We sought to study the penetration/invasion of ovarian tumor cells into extracellular matrices (ECMs) using a fibroblast-derived three-dimensional (3D) culture model and time-lapse and confocal imaging. Twelve ovarian tumor cells were evaluated and classified in...
متن کاملInvasion of waves, invasion of thoughts
Abstract Nowadays, as accepted as the era of information or digital, time has changed and has invited all people to a new world in which everybody must define himself. Avoiding from getting benefit from this human progress is useless; Rather, we must know this great technology best and adapt ourselves with its consequences. In fact, in many countries and among many nations there had been peopl...
متن کاملThe Difference of Expression of 18 Genes in Axillary Invasion and Vascular Invasion Compared to Control Samples in Breast Cancer
Background & Objective: Recent studies from gene profiling have revealed some genes that are overexpressed in the epithelial-mesenchymal transition (EMT) process and are responsible for its initiation and activation resulting in tumor progression and metastasis. The present study aimed to assess the role of genes involved in the EMT process and the association of these genes wi...
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ژورنال
عنوان ژورنال: Nature
سال: 1998
ISSN: 0028-0836,1476-4687
DOI: 10.1038/28961